Episode 3: Can science defeat ageing? CRISPR for CF; How will autonomous cars change our cities?

Genetic map of Ireland charts impact of invasions and plantations

Researchers have found relatively high levels of West Norwegian-like (probably Viking) ancestry within Ireland [Source: irishhistorypodcast.ie]
The Irish DNA Atlas which has just been published in the journal Scientific Reports provides the first fine-scale genetic map of the island of Ireland.

The DNA Atlas, which was produced by researchers at the Royal College of Surgeons and the Genealogical Society of Ireland charts the genetic impact of major historical events such as the Norse Viking invasion and the Ulster Plantations as well as revealing genetic similarity in 10 distinct clusters.

The Atlas was developed by population geneticists and genealogists who came together to collect DNA samples from 196 Irish individuals with four generations of ancestry linked to specific areas across Ireland.

The analyses of the DNA, and comparison with thousands of further samples from Britain and Europe, are revealing seven clusters of Gaelic-Irish ancestry, and three of shared British-Irish ancestry.

Scientists expect that this genetic information will improve the diagnoses of diseases where genes play a strong role, particularly for people and populations with Irish roots.

Vision 

The researchers involved in the study believe the work will help deliver on the vision of the new FutureNeuro Science Foundation Ireland Research Centre, which is seeking to improve the diagnosis of rare neurological disorders and to personalise treatments of those.

“Having a genetic map of the Irish population will be invaluable in future studies of the genetic component of some common diseases in the Irish population, especially those diseases which show a difference in prevalence rates across the island of Ireland,” said Dr Sean Ennis, UCD ACoRD and Genomics Medicine Ireland.

Some of the information the Atlas has so far revealed include the findings that there are relatively high levels of people of Northwest French and West Norwegian origin in Ireland; that there is evidence of continual, low level migration between the north of Ireland and the south and west of Scotland; and that there are three genetic clusters with shared Irish-British ancestry which are mostly found in the north of Ireland and probably stem from the Ulster plantations.

Schizophrenia linked to abnormal blood vessels in the brain

Dr Matthew Campbell, TCD, has, with co-workers, discovered a link between faulty blood vessels in the brain and the development of schizophrenia

Faults in in blood vessels in the brain may play a major role in the development of schizophrenia, a condition which affects about 1 per cent of Irish people.

That’s according to new research from scientists at at TCD and the Royal College of Surgeons in Ireland (RCSI) published in Molecular Psychiatry.

The network of blood vessels in the brain regulates the transport of energy and materials in and out of the brain, moving across the blood-brain barrier (BBB).

Abnormalities in the BBB may be a critical factor in the development of schizophrenia and other brain disorders, the Ireland-based researchers report.

“Our recent findings have, for the first time, suggested that schizophrenia is a brain disorder associated with abnormalities of brain blood vessels,” said Dr Matthew Campbell, Assistant Professor of Neurovascular Genetics at TCD.

“The concept of tailoring drugs to regulate and treat abnormal brain vessels is a novel treatment strategy and offers great potential to complement existing treatments of this debilitating disease,” said Dr Campbell.

“While it is very well accepted that improving cardiovascular health can reduce the risk of stroke and heart attacks, we now believe that drugs aimed at improving cardiovascular health may be an additional strategy to treating brain diseases in the future,” Dr Campbell added.

 

Is your cat dangerous? Microsoft aiming to ‘solve’ cancer problem; First human head transplant planned; Obesity gene & weight loss

This interview was first broadcast on the 22nd September 2016 on East Coast FM’s The Morning Show with Declan Meehan

indian-cat
Are cats a risk for to your mental and physical health, or have the risks been overblown? [Picture source: Wikipedia]

Scientists help insurers develop ‘death clock’; loneliness is bad for health; biological computers; dinosaur extinction story updated;

Listen to discussion on The Morning Show with Declan Meehan (21.04.16)

Loneliness
Loneliness puts people at higher risk from stroke, heart disease and many other illnesses (Credit: http://www.ucsf.edu)

Loneliness has been linked to a 30% increased risk of stroke. This is more evidence that being lonely, at whatever age, puts the person at higher risk of ill health.

Insurance companies, with the help of scientists,  are working on developing a ‘death clock’ which will better predict when their customers, with life insurance, will die.

Biological computers are on the way, made from genes, proteins and other living tissue, which may be used in future to diagnose and treat disease from inside the body.

The extinction of dinosaurs was prompted by the collision of a 10km wide piece of space rock with the Earth 66 million years ago, but, new evidence suggests that before the impact, the dinosaurs had already seen their best days.