Listen below to piece broadcast on RTE Radio 1 Drivetime 27-06-19 on Ireland’s role in the exciting nanomachine revolution
A technology that can light up cancerous cells during surgery promises better post-operative outcomes for patients.
The new technique precisely defines the boundaries of a cancer using chemistry, imaging technology and artificial intelligence by lighting up cancer tissue that is attached to a fluorescent agent.
It has been shown in previous research that artificial intelligence is highly effective – often more effective than human experts – when it comes to analysing medical images.
The research effort was led by Prof Donal O’Shea, Department of Chemistry at the Royal College of Surgeons in Ireland (RCSI) and published in the latest edition of Chemical Science.
The surgeons can use the technology to see lit up cancer issue through specialised cameras or microscopes, O’Shea said, and will not have to rely so heavily on their own experience when making decisions as to what tissue needs to be removed.
Currently, a surgical team can get access to a variety of different images of a patient’s tumour from technology such as CT scans, or MRI scans. These can help to locate the tumour and its size in advance, but in theatre, the surgeon is on her own.
“Quite often, depending on the tumour, they may be doing it by touch, by trying to feel the different tissues, by their experience, by visually looking at different tissues,” O’Shea said.
The new technology’s real benefit, he said, is that it can help the surgeon make decisions ‘on the spot’ as the operation takes place, and not have to rely so much on their experience alone.
“The way this works is that you would shine light on the [cancer] tissue, and if the fluorescent agent is in the tissue it will emit, or shine, light back at you at a different wavelength,” O’Shea said.
“It means you can take, or capture images, whether pictures or movies, from this fluorescent light which is being emitted from the tissue,” O’Shea said.
“When it is done clinically, or in the laboratory, there are special devices that shine the light, and essentially, there are cameras to capture the image,” O’Shea added.
The new technology can benefit the approximately 60 percent of people with solid cancer tumours – in the lung, breast, or prostate for example – who undergo surgery for their removal.
The success of these operations depends on how effectively the solid cancer is removed and how much healthy tissue remains.
“In most surgeries there isn’t a huge margin of healthy tissue,” O’Shea said. “If you can imagine it is in brain cancer, it is very, very small margins. In breast cancer similarly, there may not be a large amount of tissue that a surgeon wants to take.”
“It’s the surgical team’s decisions they are making in real time during the operations as to, do we take this portion of the tissue, or that portion of the tissue.”
The researchers aim to also use the technology to help surgeons identify whether a solid cancer has spread in a patient.
“If there was metastasis in a nearby lymph node perhaps we could detect that with our imaging agent during the surgery,” O’Shea said.
Prof O’Shea is collaborating with Prof Ronan Cahill, a colorectal surgeon in the Mater University Hospital and IBM Research in Dublin to get the technology into clinical trials in three years.
The FDA-approved alcohol aversion drug, disulfiram (Antabuse), has been found to be very effective in combating chemotherapy resistance in lung cancer.
Scientists based at TCD and St James’s Hospital, Dublin, have reported the finding for the most common type of lung cancer – non-small cell lung cancer (NSCLC) – in the journal Oncotarget.
“Disulfiram is an already approved drug will well tolerated side effects which can be taken orally,” said Dr Martin Barr, Adjust Assistant Professor and a lead investigator in the Thoracic Oncology Research Group, based at TCD and St James’s.
“Its potential use may give chemotherapeutic drugs such as cisplatin, a new lease of life in the treatment of resistant drug tumours,” Dr Barr added.
Antabuse has been used to treat alcohol addiction for over 60 years and works by restricting the activity of aldehyde dehydrogenase (ALDH) the main enzyme involved in removing alcohol from the body.
It works by preventing the body from metabolising alcohol, and so the person consuming alcohol will start to feel sick.
Antabuse has now been also found – also by inhibiting ALDH – to decrease tumour cell growth and increase the body’s killing action against lung cancer stem cells. The killing of cancer stem cells is important, because this can prevent the cancer from recurring.
The scientists at TCD and St James’s, working with the Cancer Stem Cell Group at the Coombe Hospital, Dublin, found that lung cancer cells that have high levels of ALDH activity – which is a marker for the presence of cancer stem cells, – become resistant to chemotherapy.
This resistance means that cancer cells can survive chemotherapy and may explain why a large number of lung cancer patients receiving certain types of chemotherapy suffer a relapse in their cancer afterwards.
The development of new drugs is an expensive, time consuming business, and cancer scientists have begun to assess drugs already approved to treat non cancer illness such as Antabuse, for their effectiveness against cancer.
Lung cancer is the leading cause of cancer-related deaths worldwide and accounts for more deaths than breast, colon and prostate cancer combined. In Ireland there are more than 2,300 new cases of lung cancer per year and over 1,800 deaths.
Broadcast on Drivetime on 4th August 2017
A new gene-editing tool that can precisely ‘cut and paste’ DNA to remove segments that cause disease or insert pieces that promote health benefits is, some scientists believe, as important a scientific invention as the microscope.
Scientists in Ireland are part of the what’s being called the CRISPR revolution and many biological researchers are using this technology has the potential to change the world.
From the ground-shaking discovery of the double-helix of DNA by Watson and Crick in 1953 so much followed in the years, and decades since. We have learned how DNA passing from one generation to the next, how it transmits signals to the cells, and the body, and how, when DNA building blocks get laid down in the wrong way, that it can cause sometimes deadly genetic diseases.
We are now at another historic moment in biological science, because scientists have in their hands a tool, which enables them to precisely manipulate DNA in a way that was never possible before. This tool is CRISPR and some scientists predict it could lead to the end of all genetic diseases, and perhaps even the eradication of all diseases, whether genetic or not.
Luke O’Neill is a professor of biochemistry at Trinity College, and one of the world’s leading immunologists. He is using CRISPR to study specific genes in the immune system, to change them, or modify them and see if they are important.
Breandan Kennedy, is a professor at the School of Biomolecular and Biomedical Science at UCD. He is using CRISPR to try and correct vision loss, blindness due to faulty genes and even non-inherited forms of cancer.
Dr Niall Barron is based at National Institute for Bioprocessing Research and Training, or NIBRT in Dublin. He is using CRISPR to make the manufacture of highly effective, but expensive biologically-based drugs such as Enbrel made by Pfizer in Dublin and Humira, made by Abbvie in Sligo. Both are used to treat rheumatoid arthritis.
Meanwhile, at Our Lady’s Children’s Hospital, Crumlin, Dr Terry Prendiville, a consultant paediatric cardiologist, is using CRISPR, along with colleagues based at NUI Galway, to try and repair inherited cardiac defects in children.
Dr Prendiville points out that it could be some years before CRISPR can be used to help repair the hearts of children with inherited defects.
CRISPR is described by Luke O’Neill as being as important to science as the invention of the microscope, and it has the potential to eradicate many of the debilitating and deadly diseases that are today considered incurable.
This article was published in The Medical Independent on the 17th April 2017
Interview with Myles Dungan on The History Show, RTE Radio 1, 22nd January.
The Immortal life of Henrietta Lacks based on the book written by Rebecca Skloot in 2010 will appear on our cinema screens this year, with Oprah Winfrey in the role of Henrietta.
But, who was Henrietta Lacks, what was her story, why is her life described as “immortal” and how has it influenced the lives of millions of people around the world since her death in 1951?
Henrietta Lacks was a poor black woman from the tobacco fields of the state of Virginia, USA, part of the old South.
She has made a huge contribution to mankind, because of the cells she unwittingly gave to the world, so called ‘HeLa cells’ which were taken from the cancer that killed her in 1951 and grown in labs around the world to combat disease, and help scientists develop techniques like cloning and I.V.F.
The cells have been used to produce a vaccine for polio, leading to its eradication in the USA and most parts of the world, but they have also been used to produce commercial revenue. Henrietta didn’t provide ‘consent’ for her cells to be used in this way, but in 1951, consent was not a requirement for doctors to remove cells or tissues from patients for research purposes.
Henrietta was born with the name Loretta Pleasant on the 1st August 1920 in Roanoke, the biggest town, but still a small-ish city, in southwestern Virginia. At some stage, for reasons not clear, she became Henrietta, a name that was shortened to ‘Hennie’ after the death of her mother.
Henrietta’s mother died when Henrietta was 4 and ‘Hennie’ and her nine siblings were sent to live with various aunts and uncles and cousins in the little farming town of Clover, Virginia.
Hennie ended up with her grandfather, who was also trying to raise one of Hennie’s first cousins – David. They lived in a two-story cabin built of hand-carved logs, and held together by pegs that was once the slave quarters of their ancestors.
In 1924 rural Virginia, black people were no longer slaves, but their social, economic and living circumstances, even the actual buildings that that lived in, hadn’t changed much since the Emancipation Proclamation was issued by President Abraham Lincoln on 1st January 1863. This executive order changed the federal legal status of some 3 million black slaves trapped in the Confederate south from ‘slave’ to ‘free’.
The former slave quarters that Hennie found herself living in with her grandfather and cousin David looked over the family cemetery where Hennie’s ancestors, who were black, but some of whom were also white, including one of her great grandfathers, were buried.
All around the slave house, or ‘home house’ as its residents called it were hundreds of acres of tobacco fields. The area was, and is known as Lacks Town, as many of the people living in and around the tobacco fields were ‘kin’ to Henrietta.
Hennie had honey coloured skin, a round face, and an attractive, welcoming smile. After a time, according to cousins accounts, Hennie and David, who was called ‘Day’ became an item, even though they had been raised like a brother and sister.
Children followed. Lawrence was born in 1935, and Elsie, who was “deaf and dumb”, and ended up later in a home for the Negro Insane, was born in 1939.
In 1941, Hennie and Day got married, and made plans to get out of Clover, forget the tough life of tobacco farming, and join the many black people that were heading for Baltimore and Washington DC to get jobs in the booming wartime shipyards and steel mills.
Hennie, according to accounts, settled into her new life as housewife in a brick city apartment, but she missed the country and would often grab her kids, and pile them onto a bus for a trip back to Clover.
It seems Hennie loved being a mother, and more children came with Sonny born in 1947, and Deborah in 1949. Their fifth child, Joe, was born in 1950.
A few months after Joe was born Hennie shared a secret with her cousin Sadie, Sadie later recalled. She started bleeding, even though it was not her time of the month, and one morning when she was taking a bath she felt a lump.
Hennie decided to attend the outpatient centre at Johns Hopkins Hospital in Baltimore – a renowned centre for medical excellence in February 1951 and the gynaecologist on duty when Henrietta came in was Dr Howard Jones. Dr Jones examined Henrietta and found something remarkable: a glistening, smooth growth that resembled what he called “purple Jell-O” (jelly).
The growth was about the size of a US quarter, and positioned at the lower right of Henrietta’s cervix. The growth bled easily when it was touched.
Dr Jones thought it might be an infection and tested for syphilis, but the results came back negative. He ordered a biopsy and got the diagnosis: sadly for Hennie, it was cancer.
Henrietta came back for treatment 8 days later, and another doctor took another slice off her tumour. Henrietta wasn’t told about this, but, at the time, that was normal medical practice.
Capsules of radium were placed around her cervix to try and kill the cancer cells and she was released from hospital and went home. Henrietta didn’t tell anyone about her illness, and continued with home life as normal.
She came back regularly for treatment, but the cancer cells were growing faster than radium could kill them and it was difficult for her now to hide her pain.
She was admitted to hospital for the last time in August 1951, for what would be the last time. A few months later, on 4th October 1951 Henrietta died, aged 31, with an autopsy showing that she had cancerous lumps in her chest cavity, lungs, liver, kidney and right through her bladder. The cancer had been relentless, and grew and spread at a pace that proved uncontrollable.
Henrietta was buried in an unmarked grave her the ‘home house’ in Clover. Her children remember it as a day when the rain poured from the sky as though heaven were weeping for ‘Hennie’.
The death of Hennie was devastating to Henrietta’s family, her husband Day and their five children. This is apparent, as even all these years later they get upset talking about her death, it seems.
Her death was something of a taboo subject, and no-one was comfortable talking about it, as it affected them so deeply.
Day tried to keep the show on the road by working shifts at the shipyard, while minding his three youngest children. Elsie was now in a home for the Negro Insane and family visits were not as frequent was when Henrietta was alive, as she visited Elsie regularly. Lawrence, the eldest left to join the Army.
Two relatives moved in to live with Day and the three children, one of which was described as ‘evil’ and life became brutal and horrible, with the children being beaten for no reason and having little food to eat.
As the children grew older, they – understandably – wanted to get away as much as possible from the nightmare house in Baltimore and they regularly returned to Clover to work on tobacco, as their mum had done, keeping their abuse a secret.
Elsie died in 1955, aged just 16, and it appears that sadly she had been abused, and she may even have had holes drilled in her head for some kind of human experimentation.
When Henrietta’s children had their own children, it seems that – perhaps sensing something from their parents – they too avoided the subject of their grandmother, how she lived and how she died.
Henrietta’s family knew nothing until the early 1970s when family members received phone calls from researchers asked for them to donate blood samples. The researchers said that they wanted to find out more about their mother’s genetic make-up.
Naturally, the family members wanted to know why they were interested in this, now, many years after Henrietta’s death. They were then told – and this must have been utterly shocking to them – that part of their mother, some of her cells, were still alive and growing now, more than 20 years after her death.
The Lacks family finally learned that tissue from their mother’s second biopsy in 1951 had been given to Johns Hopkins researcher Dr George Gey, who was searching for a cure to cancer, and had, towards this end, but trying – unsuccessfully – to grow human cells outside the body, so that they could be closed studied in the lab.
Dr Gey’s lab technicians got Henrietta’s cells, but – by now programmed for failure – expected them to do what many previous cell samples had done – live for a short time, a few days tops, then die. Yet, what happened astonished them. Henrietta’s cells multiplied in petri dishes, uncontrollably spreading and piling up on one another.
On the very same day that Henrietta died, 4th October 1951, Gey was appearing on a TV show called ‘Cancer Can be Conquered.” On the show he held a bottle close to the camera, and in it he said was the first human cell line ever grown. This was Henrietta’s legacy.
The cells were called “HeLa cells” by Gey, to acknowledge the first two letters of Henrietta Lacks’ first and last names. He then gave samples out to other researchers around the USA. The idea was that HeLa cells would work enough like normal cells so that doctors could test, probe and unlock their secrets and weaknesses in the lab. This new knowledge, it was hoped, would lead to a cure for cancer.
The biggest impact, without doubt, that HeLa cells have, so far at least, made on the world is by helping Jonas Salk create a vaccine which has almost eradicated – worldwide – what was a crippling disease affecting children.
Salk infected HeLa cells with the poliovirus – something that could easily be achieved – and studied how they reacted. After a number of years of work, in 1955, he had created a working vaccine.
This received huge attention because polio mainly affects children under 5 years of age, so young children had been dying and the name polio was a terrifying one until Salk came along.
Polio is highly infectious. It kills when some infected children become paralysed and their breathing muscles immobilised. It is still a threat in certain parts of the world, according to the WHO, but the number of cases, worldwide have decreased from 350,000 cases in 1988 to just 74 reported cases in 2015.
It is estimated that the polio vaccine, and, thus, HeLa cells that helped created it, have saved the lives of one million people, many of them young children, around the world since 1955, who would otherwise have died of polio.
In 1952, just three years beforehand, there was a polio outbreak in the USA which killed 3,145 people, including 1,873 children. At that rate, some 192,000 Americans would have died if the polio vaccine had not been available there from 1955.
The HeLA cells were ideal for developing a polio vaccine because they could be easily infected by poliomyelitis, which caused infected cells to die. However, a large volume of HeLa cells were needed to test Salk’s vaccine, and this led to the mass production of HeLa cells from 1953 in a cell culture ‘factory’ at Tuskegee University.
Controversially, however, companies also used HeLa cells to test cosmetics, and to measure the effects of radiation on human cells. They were used to test how human cells responded to other viruses, and were used in a number of cancer trials.
HeLa were the first ‘cell lines’, they stored well, were robust and could be sent out to laboratories all over the world. They replicate very fast, which is useful, but can also cause problems for scientists in terms of contamination of the lab.
HeLa cells have been used to study all kinds of viruses, and helped in the creation of a vaccine to HPV, the human papillomavirus, as well as to act as a testbed for new medications for cancer and Parkinson’s disease. They have also been used to test how certain products, such as cosmetics, affect human cells.
Because some HeLa cells behave differently to others, it has been possible for scientists to isolate a specific cell type, multiple it, and start a new cell line. This method of isolating a cell and keeping it alive is the basic technique behind I.V.F. which is so much part of our world today.
One discovery from HeLa cells has big potential in the fight against cancer. It was found that HeLa cells used an enzyme to repair their DNA and keep functioning when other cells would have died. Anti cancer trials against this enzyme are currently ongoing.
There are some who would say that the importance of HeLa cells in saving lives has been overstated. For example, saving one million lives with the polio vaccine, is small potatoes compared to, say the Measles vaccination, which has saved about 17 million lives since 2000.
Henrietta’s family were angry when they finally heard the full story of the HeLa cells. They felt that Johns Hopkins Hospital had removed Henrietta’s cells without permission. The hospital had done that, they didn’t deny it, and neither did they deny that they hadn’t asked permission. Permission to do this wasn’t required back in 1951.
The Lacks family were also confused by all the scientific jargon that started to come their way. I think they their initial reaction was that their mother, and themselves had been exploited by researchers. For instance, they said that they gave blood to the researchers when asked, but the researchers did not bother to follow up with them when results came out or to explain results.
None of the children have developed their mother’s aggressive cancer, so Henrietta left no deadly legacy to her children.
There was a financial issue also, as far as the Lacks family were concerned because biomedical companies in the decades since their mother’s death had been mass producing HeLa cells, like a license to print money, and sending them out all over the world.
Fortunes were being made on the back of their mother’s cells, while they themselves, could even afford health insurance.
They were also apparently hurt that so many people, researchers, scientists and doctors, appeared to know so much about their mother, and that they, her children, knew very little.
Their father Day died in 2002 (41 years after his wife Henrietta) but the family only managed recently to pool together money for a headstone for his grave.
Johns Hopkins have honoured the contribution of Henrietta, and others like her, to their research, but they remain sensitive to criticism of their role in the Lacks’ story. They made the point that the hospital as it was in 1951 can’t be judged by today’s standards, and that patient consent, now a basic standard, wasn’t even considered in 1951.
The HeLa cells, Johns Hopkins state, were given away by their researcher Dr Gey, acting on his own and the hospital never patented the HeLa cells or sold them to make money. Dr Gey, they add was acting with good intent as he passed the cells on in the hope researchers could develop a module from which scientists could learn more about human cell function (and by corally, cancer cell function).
HeLa cells have today multiplied to the point where they weigh some 20 tonnes, all together, while, according to the US Patent and Trademark Office there are close to 11,000 patents that involve HeLa cells. The cells are so widely available that they can be ordered for delivery on the Internet.
The words on Henrietta’s gravestone, composed by her grandchildren reads:
“In loving memory of a phenomenal woman, wife and mother who touched the lives of many. Here lies Henrietta Lacks (HeLa). Her immortal cells will continue to help mankind forever.”
This interview was first broadcast on the 22nd September 2016 on East Coast FM’s The Morning Show with Declan Meehan
Broadcast on Today with Sean O’Rourke [24-08-2016]
Tax incentives for those buying diesel cars over the last decade has fueled a move to diesel on Irish roads, with diesel cars now outnumbering petrol cars.
This has been widely regarded as a welcome move, as diesel cars are considered ‘better for the environment’ because they produce less carbon dioxide gases than petrol cars – the gases that have been linked with causing global warming.
However, scientific evidence is emerging which shows that the level of diesel particulates, which are damaging to human health, has increased in line with the growing popularity of diesel and that Irish people are dying as a result of this. The European Environment Agency has, for example, estimated that 1,200 people in Ireland per year are dying as a result of diseases caused by particulate pollution.
Until relatively recently, there has not been a significant amount of research into the impact of diesel pollution on public health, particularly in Europe, but the Volkswagen diesel emissions scandal certainly gave it an added push.
The evidence that is emerging from the US primarily – where research has been going on for longer – suggests that there is real reason for concern when it comes to health effects, and environmental effects, or air pollution from diesel engines. The US Environmental Protection Agency (EPA), the World Health Organisation and the UK Department of Transport have all produced reports in the last year or two which point to a real problem here.
As well as pointing to increased emissions of particulate matter (PM) and Nitrogen Dioxide gas, which are known to damage human health, the authorities in Europe and the US have started to make a direct link between an increase in numbers of people dying from respiratory diseases and cancers, and this increase in pollution.
The US EPA, who support a lot of work in this area, has led the way with publication of figures of increased numbers of premature deaths, cancers and respiratory diseases due to air pollution from diesel vehicles. There is a tangible link, a ‘smoking gun’ if you link that is linking cause and effect.
There has been little research into subject in Ireland until this year. In January 2016, a research project began at Trinity College Dublin, with funding from the Irish EPA, which is looking to precisely determine the amount of a certain type of damaging particulate, called PM 2.5 which is produced by diesel vehicles here.
It is a multi-disciplinary research effort, involving experts in air pollution, chemistry and transportation and will take place over 24 months. At the end of it, they say they will be able to determine precisely, using computer software modeling, how many deaths and illnesses here are caused by diesel vehicles.
One of the researchers involved, Dr Bidisha Ghosh, is a transportation expert, and said that the plan is to look at diesel particulates first, and to then to a follow up study where the impact of NO2 is measured and assessed.
The Irish EPA has a number of monitoring sites around Ireland that will be used as measuring points. One of the key challenges – and this is the first time anyone in the world has done this – will be to distinguish the percentage of PM 2.5 (particulate matter 2.5, a size of particulate) that is from diesel cars as opposed to other potential sources, such as sand, or the burning of coal.
The measuring sites will be near to roads as that is where diesel fumes are strongest, and another part of the study will determine how quickly dangerous diesel pollution dissipates as you move away from a busy road.
The researchers will be looking closely at what comes out of the diesel particulate filters that are attached to diesel cars. This is in order to get the chemical composition, or signature of PMs to better identify those PMs that are from diesel cars or other diesel vehicles. This is a difficult task and will involve using specialised machines to look at tiny quantities of polluting chemicals.
Dr Ghosh said that by the end of their project, in the latter part of 2017 they will be in a position to give precise numbers on the health effects of the growing use of diesel cars in Ireland. At that stage, she said they will have precise numbers on how many extra deaths, or premature deaths are being caused or what kind of extra number of lung cancers and other respiratory diseases are happening in Ireland due to us driving more diesel cars.
The calculations are based on knowledge of the car fleet, the type and age of cars on Irish roads, and knowledge of what the standard pollution emission from a certain vehicle of a certain age will be. This makes it possible to do comparison such as comparing the 2000 level of emissions versus the 2015 levels and matching the increase in pollution with the increase in deaths and diseases.
The project will also make it possible to predict, based on a number of scenarios – such as increasing use of diesel cars at the current rate – what Ireland can expect in 2020 or 2030 in terms of death rates from air pollution. This, it is hoped, will produce a solid basis for policy makers to address this problem.
The new new diesel cars on the market have very good particle filters and if you are sitting inside one of these cars you wouldn’t get a whole lot of this PM pollution, and the newer models may not pollute the atmosphere that much. The old diesels is where the big problem lies, and there are still a lot of old diesel cars being driven on Irish roads today, as they have vastly inferior emissions control technology to more modern cars.
It is also true that the bigger diesel car engines are far more polluting. The researchers at TCD, who have access to pollution figures in Ireland between 2010 and 2015 said there was a very significant increase in diesel PMs in those years, and this finding was what prompted a more detailed air pollution study.
The researchers also strongly suspect that the VW scandal wasn’t just a VW issue, and that many other diesel car makers have been cooking the books, in the sense that the emissions reported in the car manual does not bear much resemblance to the real on road emissions. The real figures, I was told, are likely to be far, far higher than what we see in the new diesel car manuals.
The Irish government started to actively support diesel from 20o8, with various tax incentives, in order to help Ireland meet its carbon dioxide ‘greenhouse gas’ targets. In fairness to the Irish government back then, the extent of the public health risk from diesel cars was not widely known.
It was initially thought that certain types of PMs were not harmful, but that thinking has changed, and now scientists are looking at the damage caused by diesel particulates that can remain wedged in the lungs. For example, the particulate, PM 1, is very hard to remove from the lung once in.
The evidence that is now emerging, however, is that not only is diesel bad for public health, it is also, by producing NO2, bad for the environment.
The science around this is all still quite new, and emerging. It is only in 2015 that a report was published by the UK authorities which stated that NO2 can also be very harmful to children, their respiratory development, their lung development and that it can cause irreversible changes.
The initial findings about the problem with diesel took time to emerge, as they didn’t perhaps fit with the green image of diesel, especially in Europe. However, the more research on this that is being done, the clearly the scientific picture becomes, and eventually, governments will have to act on the results.
Nitrous oxide, and nitrous dioxide gases from diesel cars and vehicles are also linked with health problems, and the data can be collected again by using standard emissions and examining the national car fleet. This is likely to be supported by specific EPA funded research in future, which will, like the TCD project looking at PMs, look into NO2 levels at certain EPA monitoring sites, near busy roads around the country.
Aside from being linked with respiratory disease and death, NO2 is known to have a negative impact on vegetation and acts to break down the ozone layer.
There are emerging fuels out there, such as hydrogen gas, which is being made available at existing petrol stations in the UK this summer.
However, experts believe that because the infrastructure and global distribution network is built for diesel and petrol cars, and that huge investment has been made in this system, that it will be impossible to envisage a change to any other fuel or transport type in the near, or even distant future.
Electric cars are still rare in Ireland despite significant government support, as people don’t like some of the unanswered questions that remain on it, such as how long does an electric car last, and what to do should a battery die out?
There is also the fact that a very high amount of energy can be liberated from diesel or petrol, and there is nothing that can rival petroleum on that score.
The solution, some suggest, is to truly move towards a sustainable transport system, where people walk if they can, and only use a car when they have to. Those countries that do this, and that promote public transport have far less emissions from petroleum car engines. It is also very important to think about where we locate our busy roads, as studies have shown that irreversible damage can be done to schoolchildren from air pollution in schools near such roads.
For those that need a car, the advice is to look at getting rid of the old diesel and replacing it with a new one, with better a particulate filter. Also, to avoid buying one of the high performance diesel cars and go for a more modest option.
There is also the issue in Ireland of people removing diesel particulate filters when they start to affect car performance. They can be expensive to replace, and some garages in Ireland are openly offering services on the internet to remove and not replace the filters.
A diesel car can run without a filter, and not replacing a malfunctioning filter can save hundreds if not a few thousand euros. However, from a public health and environmental perspective removing a filter is “disastrous, really, really bad” according to Dr Ghosh.
Actively preventing the removal of diesel particulate filters from diesel cars, and insisting on a high standard of operation of diesel filters as part of the NCT test, might be how the Irish government might start trying to tackle this important public health issue.
This interview was first broadcast on The Morning Show with Declan Meehan on East Coast FM (17-08-2016)
Contrary to popular belief, Men are not from Mars and women from Venus, at least when it comes to the human brain. Neuroscientists believe that the differences between male and female brains are the result of what society expects each sex to be good at.
If you need naked with your partner every night, scientists have good news for you. This practice boosts the immune system, reduces infections, and helps establish natural body rhythms, and all of his is beneficial to our health.
Scientists in Montreal have unleashed tiny nano-robots, made up largely of DNA material, which can carry drugs to where they needed inside cancer tumours. This provides a potentially more effective cancer treatment than existing therapies, which can kill healthy cells, and can’t get access inside tumours.
Black Holes are swirling cosmic whirlpools, with enormous gravitational power that suck everything, including light, and destroys it. However, Stephen Hawking predicted that not quite everything would be destroyed and some radiation, ‘Hawking radiation’, would escape. A new experiment confirms Hawking’s theory.
The colour images of the Martian surface sent back from the Viking 1 probe which landed on Mars on 20th July 1976 made world headlines.
But, did one of the three experiments onboard Viking 1 set up to test for life find evidence of life in the martian soil? Many scientists believed this 40 years ago, and many more reputable scientists believe it today.
A new gene has been found which could provide a new therapy against cancer, by cutting off its oxygen supply, and heart disease, by increasing the growth of new blood vessels.
The month of June 2016 was the hottest on record, with records going back to 1880, continuing a pattern of relentless global warming. Are we moving towards a situation where an abrupt climate change, triggered by global warming, could lead to unexpected dangerous consequences for us all?
This was first broadcast on The Morning show with Declan Meehan on East Coast FM (21/07/16)