Better treatment options for those that have suffered nerve damage can result from new research at, based at NUI Galway, according to researchers.
The treatment of peripheral nerve injuries that result in the loss of motor or sensors remains a major problem around the world.
However, new research at the Centre for Research in Medical Devices, supported by SFI, can provide improved treatment options. The results of the new study were published in the journal Advanced Functional Materials.
Researchers have used artificial nerve grafts in recent years in an attempt to restore the function of the injured peripheral nervous system; which is that part of the nervous system that lies outside the brain and spinal cord.
This study explored the differences in nerve repair that result from the use of such grafts made of two different materials: collagen and polymer PLGA.
Both collagen and PLGA have been successfully used to repair damaged nerves in the laboratory, but this success has not transferred to patients in the clinic.
The CÚRAM study results supported the idea that the success of attempts to regenerate damaged nerves is dependent on the graft material used.
The different impact of graft material had been shown by many previous studies but this CÚRAM study provides a clearer understanding of how the body responds to collagen and PLGA grafts specifically.
According to the researchers, this paves the way for the development of specific nerve regeneration strategies based on the biomaterial used.
The study focused on a non-critical nerve injury and did not incorporate the effect of increasing gap distance on the regenerative response.